P089 Patient-reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines

Abstract Background/Aims The standard measurement instruments for assessing Rheumatoid Arthritis (RA) disease activity (DA) are the Disease Activity Score with 28-Joint Count, Simple Index and Clinical Index, which all require a laboratory test joint count undertaken by health care professional. current of in RA is “Treat-to-Target”, regular assessment DA an integral part. Few healthcare providers have capacity to assess patients as frequently stipulated NICE or EULAR guidelines thus treatment not adjusted sufficiently. SARS-COV-2 pandemic has made problem more conspicuous remote rather than face-to-face consultations. Previous research suggested that Patient Reported Outcome Measures (PROMs) most informative way DA, they allow efficient use NHS resource. We therefore aimed PROMs against internationally recognised COSMIN rating PROMs. Methods PROSPERO registered CRD42020176176. This review built on previous systematic same area, PubMed EMBASE searches expanded include articles up January 2019 (rather June 2014 date) those before 1994. Some from were excluded involved biomarker and/or professional assessments. All identified rated two independent researchers, where assessed Content validity, Quality Measurement property related Risk bias following guidelines, leading recommendations use. Results 702 abstracts retrieved: 310 both EMBASE, 230 alone 162 alone. 34 given full article review, 21 included final selection. Of remaining 668, 128 selected abstract review; 58 10 selection, giving 31 total. identified: RADAI, RADAI-SF, RADAI5, PDAS2, PAS, PAS-II, RAPID3, RAPID4, PRO-CLARA GAS. Following application these articles, none could be recommended use, had sufficient evidence content validity. 5 potential but other five recommended. Conclusion lack validity major drawback PROMs, it worth noting developed created, only recently updated their increase relevance A American College Rheumatology based different criteria. Future must look Disclosure T. Pickles: None. M. Horton: K. Christensen: R. Phillips: D. Gillespie: Macefield: O. Aiyegbusi: C. Beecher: E. Choy: